Casomorphins—breakdown merchandise of casein, a milk protein, with opiate-like exercise—could assist clarify why autism signs generally enhance with a dairy-free weight-reduction plan.

In my final video sequence on autism and weight-reduction plan, I talked about the advantages of broccoli sprouts, however essentially the most generally studied dietary and dietary interventions for autism and weight-reduction plan contain variations of gluten-free and casein-free diets. Why?

Within the 1980s, a staff of revered Norwegian researchers reported a peculiar discovering. They have been evaluating the urine of youngsters with and with out autism within the hopes of teasing out any variations that might result in hints to the reason for autism. As you may see at 0:42 in my video Autism and Casein from Cow’s Milk, a urine profile exhibits spikes for every of the varied parts. Usually, the urine’s peptides area is fairly quiet. Peptides are like small items of proteins, and, usually, we shouldn’t be peeing out a lot protein. However, within the urine profiles from youngsters with autism, there have been all types of peptide spikes.

This distinction raised a query: “Can the pathophysiology”—that’s, the dysfunction—“of autism be defined by the character of the found urine peptides?” However, first: “The place do the peptides come from?” They didn’t know, however there was a clue: A lot of the mother and father of youngsters with autism reported that their youngsters’s dysfunction bought worse after they have been uncovered to cow’s milk. In reality, two proteins—gluten, a protein in wheat, and casein, a protein in milk—break down not solely into peptides, but in addition into exorphins.

Exorphins, opioid peptides derived from meals proteins, “are referred to as exorphins due to their exogenous [that is, from outside of the body] origin and morphine-like exercise,” versus endorphins, that are morphine-like compounds we produce inside our our bodies. Maybe a few of these meals peptides signify a brand new class of hormones?

Properly, is that what the youngsters have been peeing out? Apparently so, as a few of these peptides had opioid exercise. Perhaps the researchers have been on to one thing. 

Two varieties of opioids have been discovered in milk: casomorphins, “in view of their morphine-like exercise and their origin—they signify fragments of the milk protein β-casein,” and the precise opiate, morphine. There seems to be precise morphine in milk. This will’t simply be a coincidence. “It’s tough to imagine that these, or different varieties of opioids discovered within the milk, will be devoid of physiological, or dietary, significance.” If you concentrate on it, it makes whole sense. “Morphine and the opioid peptides might also have an necessary function within the mother-infant bonding mechanism, as a result of the infants could also be ‘addicted’ to their very own mom’s milk.” However, what in regards to the milk of one other species?

“Human milk is markedly completely different from that of different mammalian species” in that it has the bottom casein content material. Additional, human casein is a markedly completely different protein when it comes to its sequence of amino-acid constructing blocks.

As you may see at 3:40 in my video, human breastmilk has about 15 occasions much less casein than cow’s milk and differs in its amino acid sequence by about half, so it breaks down into peptides otherwise. “Twenty-one peptides have been recognized from cow casein proteins,” together with a number of casomorphins, in comparison with solely 5 lively peptides recognized in human milk and only one casomorphin. What’s extra, “these [casomorphins] from bovine casein are stronger than β-casomorphins from human milk.” At 4:08 in my video, you may see a graph of opioid exercise, the place decrease means stronger. Bovine casomorphin was proven to be considerably stronger than the weak opioid peptide from gluten, a substance extra similar to the casomorphin from human breastmilk.

Certainly, if you expose human nerve tissue to bovine casomorphin, it acts extra like morphine than the casomorphin from human breastmilk when it comes to epigenetic modifications, modifications in gene expression, not solely offering “a molecular rationale for the advice of breastfeeding vs. [cows’ milk] formulation feeding,” but in addition offering a attainable rationalization why “casein-free, gluten-free diets have been reported to mitigate a few of the inflammatory gastrointestinal and behavioral traits related to autism…” 

“What is good for the goose could also be good for the gander, however what is sweet for the cow may very well be dangerous to the human.” 

This text discusses the primary video in a sequence on the function of gluten- and dairy-free diets within the therapy of autism. Keep tuned for the opposite 5 movies on this six-part sequence: 

My earlier sequence on autism explored the superb story of broccoli sprouts put to the check for the therapy of autistic boys. See: 

Hold abreast of all of my movies on autism right here.

You may additionally be fascinated about these movies on milk and baby and toddler well being:

In well being, 

Michael Greger, M.D.

PS: In the event you haven’t but, you may subscribe to my free movies right here and watch my stay shows:

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